Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Mar;16(3):424-6.
doi: 10.1111/j.1468-1331.2008.02519.x.

Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis

N Putzki  1 , K Kollia, S Woods, E Igwe, H C Diener, V Limmroth
Affiliations

Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis

N Putzki et al. Eur J Neurol. 2009 Mar.

Abstract

Background: Natalizumab has been recommended for the treatment of patients with relapsing remitting multiple sclerosis with insufficient response to interferon-beta (IFN-beta) or glatiramer acetate (GA).

Method: Prospective, observational study.

Results: We found a reduction of the annualized relapse rate from 2.1 under IFN-beta or GA to 0.2 one year after switching to natalizumab. There were 94% fewer gadolinium enhancing lesions with natalizumab.

Conclusion: Natalizumab reduced short term clinical and MRI activity in second line therapy and efficacy is comparable to first line therapy as demonstrated in the pivotal trials.

PubMed Disclaimer

Comment in

MeSH terms

LinkOut - more resources