Comparative Study
doi: 10.1016/0090-6980(77)90018-1.
Modulation of human platelet adenylate cyclase by prostacyclin (PGX)
- PMID: 191876
- DOI: 10.1016/0090-6980(77)90018-1
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Comparative Study
Modulation of human platelet adenylate cyclase by prostacyclin (PGX)
Prostaglandins.
1977 Mar.
Abstract
Prostacyclin (PGX) (57)-9-deoxy-6,9alpha-epoxy-delta5-PGF1alpha has been found to be a potent stimulator of cAMP accumulation in platelets than PGE1. The prostacyclin stimulation of platelet cAMP accumulation can be antagonized by the prostaglandin endoperoxide PGH2, and a PGH2-induced platelet aggregation is antagonized by prostacyclin. A model of platelet homeostasis is proposed that suggests platelet aggregation is controlled by a balance between the adenylate cyclase stimulating activity of prostacyclin, and the cAMP lowering activity of PGH2.
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