Comment
doi: 10.1016/j.cmet.2009.01.004.
Why we should put clothes on mice
Affiliations
- PMID: 19187768
- DOI: 10.1016/j.cmet.2009.01.004
Item in Clipboard
Comment
Why we should put clothes on mice
Cell Metab.
2009 Feb.
Free article
Abstract
Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.
Comment on
-
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014. Cell Metab. 2009. PMID: 19187776
Similar articles
-
UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014. Cell Metab. 2009. PMID: 19187776
-
Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice.Am J Physiol Endocrinol Metab. 2016 Mar 1;310(5):E346-54. doi: 10.1152/ajpendo.00485.2015. Epub 2015 Dec 29. Am J Physiol Endocrinol Metab. 2016. PMID: 26714852 Free PMC article.
-
β₁-Adrenergic receptors increase UCP1 in human MADS brown adipocytes and rescue cold-acclimated β₃-adrenergic receptor-knockout mice via nonshivering thermogenesis.Am J Physiol Endocrinol Metab. 2011 Dec;301(6):E1108-18. doi: 10.1152/ajpendo.00085.2011. Epub 2011 Aug 30. Am J Physiol Endocrinol Metab. 2011. PMID: 21878665
-
Genetic variation in brown fat activity and body weight regulation in mice: lessons for human studies.Biochim Biophys Acta. 2014 Mar;1842(3):370-6. doi: 10.1016/j.bbadis.2013.04.025. Epub 2013 May 2. Biochim Biophys Acta. 2014. PMID: 23644163 Review.
-
Negative regulators of brown adipose tissue (BAT)-mediated thermogenesis.J Cell Physiol. 2014 Dec;229(12):1901-7. doi: 10.1002/jcp.24664. J Cell Physiol. 2014. PMID: 24809334 Free PMC article. Review.
Cited by
-
Peroxisome-derived lipids regulate adipose thermogenesis by mediating cold-induced mitochondrial fission.J Clin Invest. 2019 Feb 1;129(2):694-711. doi: 10.1172/JCI120606. Epub 2019 Jan 14. J Clin Invest. 2019. PMID: 30511960 Free PMC article.
-
Lifespan of long-lived growth hormone receptor knockout mice was not normalized by housing at 30°C since weaning.Aging Cell. 2020 May;19(5):e13123. doi: 10.1111/acel.13123. Epub 2020 Feb 28. Aging Cell. 2020. PMID: 32110850 Free PMC article.
-
Knockout mouse models of insulin signaling: Relevance past and future.World J Diabetes. 2014 Apr 15;5(2):146-59. doi: 10.4239/wjd.v5.i2.146. World J Diabetes. 2014. PMID: 24748928 Free PMC article. Review.
-
Setting Ambient Temperature Conditions to Optimize Translation of Molecular Work from the Mouse to Human: The "Goldilocks Solution".Methods Mol Biol. 2022;2448:235-250. doi: 10.1007/978-1-0716-2087-8_15. Methods Mol Biol. 2022. PMID: 35167101
-
Comparative proteomic study of liver lipid droplets and mitochondria in mice housed at different temperatures.FEBS Lett. 2019 Aug;593(16):2118-2138. doi: 10.1002/1873-3468.13509. Epub 2019 Jul 12. FEBS Lett. 2019. PMID: 31234227 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Research Materials
