Comment
doi: 10.1016/j.cmet.2009.01.004.
Why we should put clothes on mice
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- PMID: 19187768
- DOI: 10.1016/j.cmet.2009.01.004
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Comment
Why we should put clothes on mice
Cell Metab.
2009 Feb.
Free article
Abstract
Mitochondrial uncoupling protein 1 (UCP1) is a key regulator of adaptive thermogenesis and energy expenditure. Mice lacking UCP1 are cold sensitive, but surprisingly not obese at room temperature. In this issue of Cell Metabolism, Feldmann et al. (2009) unmask an obesogenic phenotype by simply maintaining these mice at thermoneutrality.
Comment on
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UCP1 ablation induces obesity and abolishes diet-induced thermogenesis in mice exempt from thermal stress by living at thermoneutrality.Cell Metab. 2009 Feb;9(2):203-9. doi: 10.1016/j.cmet.2008.12.014. Cell Metab. 2009. PMID: 19187776
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