Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Nov;13(6):740-4.
doi: 10.1016/j.ijid.2008.11.016. Epub 2009 Feb 1.

Mycobacterium tuberculosis and Mycobacterium africanum in stools from children attending an immunization clinic in Ibadan, Nigeria

S I B Cadmus  1 , A O Jenkins, J Godfroid, K Osinusi, I F Adewole, R L Murphy, B O Taiwo
Affiliations

Mycobacterium tuberculosis and Mycobacterium africanum in stools from children attending an immunization clinic in Ibadan, Nigeria

S I B Cadmus et al. Int J Infect Dis. 2009 Nov.

Abstract

Background: Tuberculosis is a major cause of childhood morbidity and mortality in Nigeria. Diagnosis of childhood tuberculosis is a global challenge making early treatment a mirage. In this study we investigated the stools of children for the presence of mycobacteria.

Methods: Stool samples from children aged 3 days to 3 years who presented for postnatal immunization at a large university-based clinic in Nigeria, were subjected to Ziehl-Neelsen staining. Samples with acid-fast bacilli were further processed using mycobacterial culture, spoligotyping, and deletion typing.

Results: One hundred and ninety-two stool samples from different children were collected and processed. Thirty (15.6%) had acid-fast bacilli. Of these, eight had Mycobacterium tuberculosis and one had Mycobacterium africanum.

Conclusions: Approximately 5% (9/192) of apparently well children had evidence of potentially serious tuberculosis infection. The usefulness of stool specimens for diagnosing pediatric tuberculosis warrants further investigation.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST: NONE

Figures

Figure 1
Figure 1
Spoligoype profile of Pediatric Patients with Positive Culture Result for Mycobacterium tuberculosis complex
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. WHO. WHO report 2007. Geneva: World Health Organization; 2007. [Accessed 27th of April, 2008]. Global tuberculosis control: surveillance, planning, financing. (WHO/HTM.TB/2007.376). http://www.who.int/tb/publications/global_report/2007/en/index.html.
    1. Corbett EL, Watt CJ, Walker N, et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med. 2003;163:1009–1021. - PubMed
    1. Morcillo N. Tuberculosis in children. In: Palomino JC, Leao SC, Ritacco V, editors. Tuberculosis 2007 from basic science to patient care. Bernard Sebastian Kamps and Patricia Bourcillier Fund; Belgium, Brazil, Argentina: [Accessed 24th April 2008]. pp. 525–558. http://www.tuberculosistextbook.com.
    1. Osinusi K. Clinical and epidemiological features of childhood tuberculosis in Ibadan, Nigerian. J Paediatr. 1998;25:15–19.
    1. Rheka B, Swaminathan S. Childhood tuberculosis-global epidemiology and the impact of HIV. Pediatric Resp Rev. 2007;8:99–106. - PubMed

Publication types

MeSH terms