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. 2009 Nov;13(6):740-4.
doi: 10.1016/j.ijid.2008.11.016. Epub 2009 Feb 1.

Mycobacterium tuberculosis and Mycobacterium africanum in stools from children attending an immunization clinic in Ibadan, Nigeria

S I B Cadmus  1 , A O Jenkins, J Godfroid, K Osinusi, I F Adewole, R L Murphy, B O Taiwo
Affiliations

Mycobacterium tuberculosis and Mycobacterium africanum in stools from children attending an immunization clinic in Ibadan, Nigeria

S I B Cadmus et al. Int J Infect Dis. 2009 Nov.

Abstract

Background: Tuberculosis is a major cause of childhood morbidity and mortality in Nigeria. Diagnosis of childhood tuberculosis is a global challenge making early treatment a mirage. In this study we investigated the stools of children for the presence of mycobacteria.

Methods: Stool samples from children aged 3 days to 3 years who presented for postnatal immunization at a large university-based clinic in Nigeria, were subjected to Ziehl-Neelsen staining. Samples with acid-fast bacilli were further processed using mycobacterial culture, spoligotyping, and deletion typing.

Results: One hundred and ninety-two stool samples from different children were collected and processed. Thirty (15.6%) had acid-fast bacilli. Of these, eight had Mycobacterium tuberculosis and one had Mycobacterium africanum.

Conclusions: Approximately 5% (9/192) of apparently well children had evidence of potentially serious tuberculosis infection. The usefulness of stool specimens for diagnosing pediatric tuberculosis warrants further investigation.

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Conflict of interest statement

CONFLICT OF INTEREST: NONE

Figures

Figure 1
Figure 1
Spoligoype profile of Pediatric Patients with Positive Culture Result for Mycobacterium tuberculosis complex
See this image and copyright information in PMC

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