Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Mar;10(3):207-16.
doi: 10.1038/nrg2505.

The consequences of asynapsis for mammalian meiosis

Paul S Burgoyne  1 , Shantha K Mahadevaiah, James M A Turner
Affiliations
Review

The consequences of asynapsis for mammalian meiosis

Paul S Burgoyne et al. Nat Rev Genet. 2009 Mar.

Abstract

During mammalian meiosis, synapsis of paternal and maternal chromosomes and the generation of DNA breaks are needed to allow reshuffling of parental genes. In mammals errors in synapsis are associated with a male-biased meiotic impairment, which has been attributed to a response to persisting DNA double-stranded breaks in the asynapsed chromosome segments. Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. PLoS Biol. 2004 Jan;2(1):E21 - PubMed
    1. Chromosoma. 1986;94(2):115-24 - PubMed
    1. Science. 2002 Jun 21;296(5576):2181-3 - PubMed
    1. Mol Cell. 1998 Apr;1(5):697-705 - PubMed
    1. Nat Genet. 2004 Jun;36(6):642-6 - PubMed

LinkOut - more resources