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. 2009 Feb 3;6(2):e25.
doi: 10.1371/journal.pmed.1000025.

Ovarian cancer: a clinical challenge that needs some basic answers

Kate Lawrenson  1 , Simon A Gayther
Affiliations

Ovarian cancer: a clinical challenge that needs some basic answers

Kate Lawrenson et al. PLoS Med. .

Abstract

Kate Lawrenson and Simon Gayther discuss two studies of ovarian cancer inPLoS Medicine, one on clinico-pathological heterogeneity and one on gene expression profiling.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Histological and Molecular Heterogeneity in Epithelial Ovarian Cancers
Common genetic alterations vary between different epithelial ovarian cancer sub-types. Highlighted in red are genes/pathways commonly inactivated in tumours; highlighted in green are genes commonly activated or amplified in epithelial ovarian cancer tumour specimens. Hematoxylin and eosin stained sections show typical histological and architectural appearance of the high-grade serous, borderline serous, mucinous, clear cell, and endometrioid sub-types. Biomarkers listed are those found in the study by Huntsman and colleagues to be highly expressed (i.e., samples positive in over 60% of tumours, green arrow), or lowly expressed (red arrow) in each histological sub-type. Median Ki67 labelling indices (a measure of the proportion of proliferating cells in a tumour sample) are given in bold type.
See this image and copyright information in PMC

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