Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Apr;2(2):229-237.
doi: 10.2217/17460875.2.2.229.

Triacylglycerol metabolism in adipose tissue

Maryam Ahmadian  1 , Robin E Duncan, Kathy Jaworski, Eszter Sarkadi-Nagy, Hei Sook Sul
Affiliations

Triacylglycerol metabolism in adipose tissue

Maryam Ahmadian et al. Future Lipidol. 2007 Apr.

Abstract

Triacylglycerol (TAG) in adipose tissue serves as the major energy storage form in higher eukaryotes. Obesity, resulting from excess white adipose tissue, has increased dramatically in recent years resulting in a serious public health problem. Understanding of adipocyte-specific TAG synthesis and hydrolysis is critical to the development of strategies to treat and prevent obesity and its closely associated diseases, for example, Type 2 diabetes, hypertension and atherosclerosis. In this review, we present an overview of the major enzymes in TAG synthesis and lipolysis, including the recent discovery of a novel adipocyte TAG hydrolase.

PubMed Disclaimer

Figures

Figure 1
Figure 1. The enzymes of triacylglycerol synthesis and hydrolysis
AGPAT: 1-acylglycerol-3-phosphate acyltransferase; ATGL: Adipose triglyceride lipase; CoA: Coenzyme A; DGAT: Diacylglycerol acyltransferase; DHAP: Dihydroxyacetone-phosphate; DHAPAT: Acyl-CoA:dihydroxyacetone-phosphate acyltransferase; DHAP-OR: Dihydroxyacetone-phosphate oxido-reductase; FA: Fatty acid; GPAT: Glycerol-3-phosphate acyltransferase; HSL: Hormone-sensitive lipase; MGL: Monoglyceride lipase; PAP: Phosphatidic acid phosphatase; TAG: Triacylglycerol.
See this image and copyright information in PMC

References

    1. Gregoire FM, Smas CM, Sul HS. Understanding adipocyte differentiation. Physiol. Rev. 1998;78(3):783–809. - PubMed
    1. Walley AJ, Blakemore AI, Froguel P. Genetics of obesity and the prediction of risk for health. Hum. Mol. Genet. 2006;15(Suppl 2):R124–R130. - PubMed
    1. Agarwal AK, Garg A. Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways. Trends Endocrinol. Metab. 2003;14(5):214–221. - PubMed
    1. Bhayana S, Hegele RA. The molecular basis of genetic lipodystrophies. Clin. Biochem. 2002;35(3):171–177. - PubMed
    1. Reitman ML. Metabolic lessons from genetically lean mice. Annu. Rev. Nutr. 2002;22:459–482. - PubMed

LinkOut - more resources