Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 May;32(5):883-8.
doi: 10.2337/dc08-2005. Epub 2009 Feb 5.

Structural and functional cardiac abnormalities in adolescent girls with poorly controlled type 2 diabetes

Gillian A Whalley  1 , Silmara Gusso, Paul Hofman, Wayne Cutfield, Katrina K Poppe, Robert N Doughty, J Chris Baldi
Affiliations

Structural and functional cardiac abnormalities in adolescent girls with poorly controlled type 2 diabetes

Gillian A Whalley et al. Diabetes Care. 2009 May.

Abstract

Objective: Type 2 diabetes is associated with left ventricular hypertrophy (LVH) and diastolic dysfunction, which may eventually lead to clinical heart failure. We sought to determine the cardiovascular effects of adolescent-onset type 2 diabetes.

Research design and methods: We recruited diabetic girls (8 with type 2 and 11 with type 1 diabetes) from a hospital diabetes service and nondiabetic control subjects (9 lean and 11 overweight) from the schools of the diabetic subjects. Echocardiography and measurements were performed by a single observer, blinded to subject group allocation, and included M-mode left ventricular dimensions, two-dimensional left ventricular mass, Doppler diastolic flows, estimation of left ventricular filling pressure, and systolic longitudinal motion. Left ventricular mass was indexed to height and fat-free body mass. ANOVA was used to compare the groups.

Results: The groups were similar in age and height, but significant differences in body composition were observed. Subjects with type 2 diabetes had larger left ventricular dimensions and left ventricular mass, which persisted when indexed to height. Diastolic filling was impaired in both diabetic groups, and systolic longitudinal function was lower in the type 2 diabetic group. Half of the group with type 2 diabetes met the published criteria for LVH and left ventricular dilatation; 25% had evidence of elevated left ventricular filling pressure in association with structural abnormalities.

Conclusions: This study has demonstrated preclinical abnormalities of cardiac structure and function in adolescent girls with type 2 diabetes, despite the short duration of diabetes and highlights the potential high cardiovascular risk occurring in adolescent type 2 diabetes.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Left ventricular (LV) mass by group: LV mass (A), LV mass/height (B), and LV mass/FFM (C).T1DM, type 1 diabetes; T2DM, type 2 diabetes.
Figure 2
Figure 2
Pulsed-wave tissue Doppler velocities. Average Ea velocity (A), average Sa (B), and average E:Ea (C). T1DM, type 1 diabetes; T2DM, type 2 diabetes; TDI, tissue Doppler imaging.
See this image and copyright information in PMC

References

    1. Hillier TA, Pedula KL: Complications in young adults with early-onset type 2 diabetes. Diabetes Care 2003; 26: 2999– 3005 - PubMed
    1. Pinhas-Hamiel O, Zeitler P: Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet 2007; 369: 1823– 1831 - PubMed
    1. Morrish NJ, Wang SL, Stevens LK, Fuller JH, Keen H: Mortality and causes of death in the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 2001; 44: S14– S21 - PubMed
    1. Lee ET, Lu M, Bennett PH, Keen H: Vascular disease in younger-onset diabetes: comparison of European, Asian and American Indian cohorts of the WHO Multinational Study of Vascular Disease in Diabetes. Diabetologia 2001; 44: S78– S81 - PubMed
    1. Yokoyama H, Okudaira M, Otani T, Takaike H, Miura J, Saeki A, Uchigata Y, Omori Y: Existence of early-onset NIDDM Japanese demonstrating severe diabetic complications. Diabetes Care 1997; 20: 844– 847 - PubMed

Publication types

MeSH terms