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. 2009 Mar;41(3):280-2.
doi: 10.1038/ng.307. Epub 2009 Feb 8.

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann  1 , Anika Grosshennig, Peter S Braund, Inke R König, Christian Hengstenberg, Alistair S Hall, Patrick Linsel-Nitschke, Sekar Kathiresan, Ben Wright, David-Alexandre Trégouët, Francois Cambien, Petra Bruse, Zouhair Aherrahrou, Arnika K Wagner, Klaus Stark, Stephen M Schwartz, Veikko Salomaa, Roberto Elosua, Olle Melander, Benjamin F Voight, Christopher J O'Donnell, Leena Peltonen, David S Siscovick, David Altshuler, Piera Angelica Merlini, Flora Peyvandi, Luisa Bernardinelli, Diego Ardissino, Arne Schillert, Stefan Blankenberg, Tanja Zeller, Philipp Wild, Daniel F Schwarz, Laurence Tiret, Claire Perret, Stefan Schreiber, Nour Eddine El Mokhtari, Arne Schäfer, Winfried März, Wilfried Renner, Peter Bugert, Harald Klüter, Jürgen Schrezenmeir, Diana Rubin, Stephen G Ball, Anthony J Balmforth, H-Erich Wichmann, Thomas Meitinger, Marcus Fischer, Christa Meisinger, Jens Baumert, Annette Peters, Willem H Ouwehand; Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics Consortium; Panos Deloukas, John R Thompson, Andreas Ziegler, Nilesh J Samani, Heribert Schunkert
Affiliations

New susceptibility locus for coronary artery disease on chromosome 3q22.3

Jeanette Erdmann et al. Nat Genet. 2009 Mar.

Abstract

We present a three-stage analysis of genome-wide SNP data in 1,222 German individuals with myocardial infarction and 1,298 controls, in silico replication in three additional genome-wide datasets of coronary artery disease (CAD) and subsequent replication in approximately 25,000 subjects. We identified one new CAD risk locus on 3q22.3 in MRAS (P = 7.44 x 10(-13); OR = 1.15, 95% CI = 1.11-1.19), and suggestive association with a locus on 12q24.31 near HNF1A-C12orf43 (P = 4.81 x 10(-7); OR = 1.08, 95% CI = 1.05-1.11).

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Figures

Figure 1
Figure 1. Association results from Stage 1
(a) 3q22.3 locus. (b) 12q24.31 locus. Genomic positions refer to the UCSC Genome Browser Human March 2006. Presented are SNPs that passed quality control in stage 1. The GWAS P value for the lead SNPs (rs9818870 (3q22.3), rs2259816 (12q24.31)) is denoted by a red diamond. Blue diamonds indicate P values for the lead SNPs in the replication sample. Proxies are indicated with diamonds of smaller size, with colors determined from their pairwise r2 from HapMap CEU (red: high LD with lead SNP (r2 > 0.8); orange: moderate LD with lead SNP (0.5 < r2 < 0.8); yellow: weak LD with lead SNP (0.2 < r2 < 0.5); white: no LD with the lead SNP (r2 < 0.2) or no information available). The locations of the UCSC genes in the region and recombination rates and hot spots as defined previously are shown.
See this image and copyright information in PMC

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