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. 2009 Feb 7:7:11.
doi: 10.1186/1477-7525-7-11.

Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment

Merel L Kimman  1 , Carmen D Dirksen, Philippe Lambin, Liesbeth J Boersma
Affiliations

Responsiveness of the EQ-5D in breast cancer patients in their first year after treatment

Merel L Kimman et al. Health Qual Life Outcomes. .

Abstract

Background/aim: The EQ-5D is a generic health-related quality of life (HRQoL) measure that is used for the purpose of economic evaluations of health interventions. Therefore, it has to be responsive to meaningful changes in health in the patient population under investigation. The aim of this study was to investigate the responsiveness of the EQ-5D in breast cancer patients in their first year after treatment.

Methods: The subscale global health of the disease-specific HRQoL measure EORTC QLQ-C30 was used as a reference instrument to determine meaningful changes in health and identify subgroups of patients: patients reporting a moderate-large deterioration, small deterioration, a small improvement, moderate-large improvement, or no change in health status. Responsiveness was evaluated by calculating standardized response means (SRMs) in the five subgroups of patients and performing analysis of variance procedures. The two HRQoL measures were filled out two weeks and one year after finalizing curative treatment for breast cancer (n = 192).

Results: The EQ-5D was able to capture both improvements and deteriorations in HRQoL. SRMs of the EQ VAS and EQ-5D Index were close to zero in the subgroup reporting no change and increased and decreased adequately in the subgroups reporting small and moderate changes. Additional analysis of variance procedures showed that the EQ-5D was able to differentiate between subgroups of patients with no change and moderate-large deterioration or improvement in health.

Conclusion: The EQ-5D seems an appropriate measure for the purpose of economic evaluations of health intervention in breast cancer patients after treatment.

Trial registration: Current Controlled Trials ISRCTN74071417.

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References

    1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108. doi: 10.3322/canjclin.55.2.74. - DOI - PubMed
    1. ESMO ESMO Minimum Clinical Recommendations for diagnosis, adjuvant treatment and follow-up of primary breast cancer. Ann Oncol. 2001;12:1047–1048. doi: 10.1023/A:1017448816215. - DOI - PubMed
    1. Khatcheressian JL, Wolff AC, Smith TJ, Grunfeld E, Muss HB, Vogel VG, Halberg F, Somerfield MR, Davidson NE. American Society of Clinical Oncology 2006 update of the breast cancer follow-up and management guidelines in the adjuvant setting. J Clin Oncol. 2006;24:5091–5097. doi: 10.1200/JCO.2006.08.8575. - DOI - PubMed
    1. de Bock GH, Bonnema J, Hage J van der, Kievit J, Velde CJ van de. Effectiveness of routine visits and routine tests in detecting isolated locoregional recurrences after treatment for early-stage invasive breast cancer: a meta-analysis and systematic review. J Clin Oncol. 2004;22:4010–4018. doi: 10.1200/JCO.2004.06.080. - DOI - PubMed
    1. Jacobs HJ, van Dijck JA, de Kleijn EM, Kiemeney LA, Verbeek AL. Routine follow-up examinations in breast cancer patients have minimal impact on life expectancy: a simulation study. Ann Oncol. 2001;12:1107–1113. doi: 10.1023/A:1011624829512. - DOI - PubMed

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