Balancing out the ends during iPSC nuclear reprogramming
- PMID: 19200794
- DOI: 10.1016/j.stem.2009.01.004
Balancing out the ends during iPSC nuclear reprogramming
Abstract
In this issue of Cell Stem Cell, Marion et al. (2009) report that efficient production of iPSCs requires active telomerase, which allows the rejuvenation of telomeres to a state similar to that observed in embryonic stem cells, even in iPSCs generated from old donor cells.
Comment on
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Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells.Cell Stem Cell. 2009 Feb 6;4(2):141-54. doi: 10.1016/j.stem.2008.12.010. Cell Stem Cell. 2009. PMID: 19200803
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