The MLLgnant consequences of reverting to an embryonic transcriptional program
- PMID: 19200795
- DOI: 10.1016/j.stem.2009.01.008
The MLLgnant consequences of reverting to an embryonic transcriptional program
Abstract
In this issue of Cell Stem Cell, Somervaille et al. (2009) have demonstrated convincingly that reversion to an embryonic transcriptional program through defective MLL gene expression contributes to the generation of myeloid leukemia stem cells.
Comment on
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Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells.Cell Stem Cell. 2009 Feb 6;4(2):129-40. doi: 10.1016/j.stem.2008.11.015. Cell Stem Cell. 2009. PMID: 19200802 Free PMC article.
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