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Review
. 2009 Feb 15;87(3):309-16.
doi: 10.1097/TP.0b013e31819535c2.

Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials

Megan Sykes  1
Affiliations
Review

Hematopoietic cell transplantation for tolerance induction: animal models to clinical trials

Megan Sykes. Transplantation. .

Abstract

The induction of donor-specific immune tolerance is the "holy grail" of transplantation, as it would avoid the toxicities of chronic immunosuppressive therapies while preventing acute and chronic graft rejection. A large number of approaches to tolerance induction have been described in the experimental literature, but only hematopoietic cell transplantation has shown preliminary success for intentional tolerance induction in pilot clinical trials. This review summarizes the conditions that allow progress to be made in moving strategies for tolerance induction from the bench to the bedside and discuss the mechanisms by which tolerance may be achieved through hematopoietic cell transplantation.

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Figures

Figure 1
Figure 1
Protocol for combined HLA-mismatched (haploidentical donor) kidney and bone marrow transplantation used for Immune Tolerance Network trial NKDO3. * components of the regimen that were added after the third transplant (i.e. given only to Patients 4 and 5).
See this image and copyright information in PMC

References

    1. Billingham RE, Brent L, Medawar PB. “Actively acquired tolerance” of foreign cells. Nature. 1953;172:603–606. - PubMed
    1. Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA. 1997;94:8789–8798. - PMC - PubMed
    1. Kirk AD, Burkly LC, Batty DS, et al. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nature Med. 1999;5:686–693. - PubMed
    1. Kirk AD, Tadaki DK, Celniker A, et al. Induction therapy with monoclonal antibodies specific for cd80 and cd86 delays the onset of acute renal allograft rejection in non-human primates1. Transplantation. 2001;72:377–384. - PubMed
    1. Elster EA, Xu H, Tadaki DK, et al. Treatment with the humanized CD154-specific monoclonal antibody, hu5C8, prevents acute rejection of primary skin allografts in nonhuman primate. Transplantation. 2001;72:1473–1478. - PubMed

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