Long-term association of food and nutrient intakes with cognitive and functional decline: a 13-year follow-up study of elderly French women

Abstract

The objective of the present study was to determine the potential long-term impact of dietary habits on age-related decline among 4809 elderly women (born between 1925 and 1930) in the 'Etude Epidémiologique de Femmes de la Mutuelle Générale de l'Education Nationale' (E3N) study, a French epidemiological cohort. In 1993, an extensive diet history self-administered questionnaire was sent to all participants, and in 2006 another questionnaire on instrumental activities of daily living (IADL) and recent cognitive change was sent to a close relative or friend of each woman. Logistic models adjusted for socio-demographic, lifestyle and health factors were performed to evaluate associations between habitual dietary intakes and two outcomes of interest based on the informant response: recent cognitive decline and IADL impairment. Recent cognitive decline was associated with lower intakes of poultry, fish, and animal fats, as well as higher intakes of dairy desserts and ice-cream. IADL impairment was associated with a lower intake of vegetables. The odds of recent cognitive decline increased significantly with decreasing intake of soluble dietary fibre and n-3 fatty acids but with increasing intake of retinol. The odds of IADL impairment increased significantly with decreasing intakes of vitamins B2, B6 and B12. These results are consistent with a possible long-term neuroprotective effect of dietary fibre, n-3 polyunsaturated fats and B-group vitamins, and support dietary intervention to prevent cognitive decline.

Figure 1

Cognitive decline and functional impairment: Kernel density estimation of the DECO score according to the 4-IADL score¹, E3N Study², France, 2006 DECO, questionnaire “Détérioration Cognitive Observée”; IADL, Instrumental Activities of Daily Living; E3N, “Etude Epidémiologique de Femmes de la Mutuelle Générale de l’Education Nationale”; ¹ 4-IADL score defined as number of limitations to the subject’s ability to use the telephone, take medication, use public transport and manage own budget ² The analysis was conducted among the 4,758 subjects for whom both scores were computable