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doi: 10.1016/j.cell.2009.01.021.
An amino acid shuffle activates mTORC1
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- PMID: 19203575
- DOI: 10.1016/j.cell.2009.01.021
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An amino acid shuffle activates mTORC1
Cell.
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Abstract
The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.
Comment on
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Bidirectional transport of amino acids regulates mTOR and autophagy.Cell. 2009 Feb 6;136(3):521-34. doi: 10.1016/j.cell.2008.11.044. Cell. 2009. PMID: 19203585 Free PMC article.
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