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Comment
. 2009 Feb 6;136(3):399-400.
doi: 10.1016/j.cell.2009.01.021.

An amino acid shuffle activates mTORC1

Adiel Cohen  1 , Michael N Hall
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Free article
Comment

An amino acid shuffle activates mTORC1

Adiel Cohen et al. Cell. .
Free article

Abstract

The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.

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  • Bidirectional transport of amino acids regulates mTOR and autophagy.
    Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B, Yang H, Hild M, Kung C, Wilson C, Myer VE, MacKeigan JP, Porter JA, Wang YK, Cantley LC, Finan PM, Murphy LO. Nicklin P, et al. Cell. 2009 Feb 6;136(3):521-34. doi: 10.1016/j.cell.2008.11.044. Cell. 2009. PMID: 19203585 Free PMC article.

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