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Clinical Trial
. 2008 Nov-Dec;9(6):434-9.
doi: 10.1310/hct0906-434.

Simplification of the research diagnosis of HIV-associated sensory neuropathy

Scott R Evans  1 , David B Clifford, Douglas W Kitch, Karl Goodkin, Giovanni Schifitto, Justin C McArthur, David M Simpson
Affiliations
Clinical Trial

Simplification of the research diagnosis of HIV-associated sensory neuropathy

Scott R Evans et al. HIV Clin Trials. 2008 Nov-Dec.

Abstract

Peripheral neuropathy (PN) is the most common neurological complication of HIV infection,affecting over one third of patients. The research diagnosis of PN is complicated by the need for expensive, time-consuming, and noxious diagnostic tests. We investigated whether nerve conduction studies (NSC) and quantitative sensory tests (QST) provide added value for the diagnosis of PN for research purposes or whether the easily obtainable clinical measures (sensory and motor symptoms, sensitivity to pain and vibration, tendon reflexes, motor function) are sufficient.

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Figures

Figure 1
Figure 1
Receiver operating characteristic curves by step for evaluation of the gain in diagnostic accuracy by the addition of quantitative tests over clinical measures. SS = sensory symptoms; MS = motor symptoms; PS = pin sensitivity; VS = vibration sensitivity; TR = tendon reflexes; QST = quantitative sensory tests; SA = sural amplitude; PA = peroneal amplitude; T = thigh; DL = distal leg; CD = cooling detection; VD = vibration detection.
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References

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