Changes of rat cerebellar guanosine 3',5'-cyclic phosphate by dopaminergic mechanisms in vivo
- PMID: 192051
Item in Clipboard
Changes of rat cerebellar guanosine 3',5'-cyclic phosphate by dopaminergic mechanisms in vivo
Adv Biochem Psychopharmacol.
1976.
Abstract
Apomorphine produced a dose-dependent increase of the cGMP level in the cerebellum. Haloperidol and scopolamine completely prevented this increase, and reserpine reduced the increase to 50%. LSD elevated cerebellar cGMP, and this effect was also abolished by haloperidol. It is suggested that the primary site of action of these drugs is the caudate nucleus, from which two neuronal pathways could trigger the increase of cGMP in the cerebellum.
Similar articles
-
In vivo changes of guanosine 3',5'-cyclic phosphate in rat cerebellum by dopaminergic mechanisms.J Neurochem. 1976 Jul;27(1):297-8. doi: 10.1111/j.1471-4159.1976.tb01581.x. J Neurochem. 1976. PMID: 182922 No abstract available.
-
Pharmacologically induced changes in the 3':5'-cyclic guanosine monophosphate content of rat cerebellar cortex: difference between apomorphine, haloperidol and harmaline.J Pharmacol Exp Ther. 1977 Jan;200(1):207-15. J Pharmacol Exp Ther. 1977. PMID: 13199
-
Different mechanisms mediating the decrease of cerebellar cGMP elicited by haloperidol and diazepam.Adv Biochem Psychopharmacol. 1976;15:325-35. Adv Biochem Psychopharmacol. 1976. PMID: 192052 Review. No abstract available.
-
Scopolamine-induced hypermotility in rats is mediated via a dopaminergic system.Acta Biol Med Ger. 1980;39(8-9):903-10. Acta Biol Med Ger. 1980. PMID: 7282220
-
Striato-cerebellar pathway controlling cyclic GMP content in the cerebellum: role of dopamine, GABA and enkephalins.Adv Biochem Psychopharmacol. 1978;18:227-44. Adv Biochem Psychopharmacol. 1978. PMID: 206110 Review. No abstract available.
Cited by
-
Regression of cerebellar syndrome with long-term administration of 5-HTP or the combination 5-HTP-benserazide.Ital J Neurol Sci. 1984 Sep;5(3):253-66. doi: 10.1007/BF02043955. Ital J Neurol Sci. 1984. PMID: 6334064
-
Kainic acid-induced lesion of dopaminergic target cells in the striatum: consequences on the dynamics of cerebellar cGMP.Naunyn Schmiedebergs Arch Pharmacol. 1978 Aug;304(1):5-7. doi: 10.1007/BF00501370. Naunyn Schmiedebergs Arch Pharmacol. 1978. PMID: 211448