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. 2009 Aug;135(8):1117-23.
doi: 10.1007/s00432-009-0553-0. Epub 2009 Feb 10.

Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience

Kenji Hashimoto  1 , Hiroshi Mayahara, Atsuo Takashima, Takako Eguchi Nakajima, Ken Kato, Tetsuya Hamaguchi, Yoshinori Ito, Yasuhide Yamada, Yoshikazu Kagami, Jun Itami, Yasuhiro Shimada
Affiliations

Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience

Kenji Hashimoto et al. J Cancer Res Clin Oncol. 2009 Aug.

Abstract

Purpose: To clarify the toxicity of palliative radiotherapy (RT) and its efficacy against bleeding of unresectable gastric cancer.

Methods: Clinical data of 19 patients received palliative RT for bleeding from unresectable gastric cancer were reviewed. The median total dose and dose per fraction were 40 Gy (range 2-50 Gy) and 2.5 Gy (range 1.8-3 Gy).

Results: The treatment success rate was 68.4%. By using a tumor alpha/beta ratio of 10, biological effective dose of 50 Gy(10) or more was significantly correlated with treatment success (P = 0.040). The median event-free survival was 1.5 months after RT and the median overall survival from starting RT was 3.4 months. Grade 3 nausea and anorexia were recorded in 1 and 3 patients, respectively.

Conclusion: Palliative RT was effective for hemostasis in patients with gastric cancer bleeding with minor adverse events.

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Figures

Fig. 1
Fig. 1
Typical endoscopic findings. a Hemorrhagic gastric cancer of stomach body before radiation therapy. b Complete hemostasis following radiation therapy (40 Gy) of the same site
Fig. 2
Fig. 2
Dose–effect relationship
Fig. 3
Fig. 3
Event-free survival from the day of completing radiation
Fig. 4
Fig. 4
Survival from the day of starting radiation
See this image and copyright information in PMC

References

    1. Coia LR, Paul AR, Engstorm PF (1988) Combined radiation and chemotherapy as primary management of adenocarcinoma of esophagus and gastroesophageal junction. Cancer 61:643–649. doi:10.1002/1097-0142(19880215)61:4%3c643::AID-CNCR2820610404%3e3.0.CO;2-4 - PubMed
    1. Encarnacion CE, Kadir S, Beam CA, Payne CS (1992) Gastrointestinal bleeding: treatment with gastrointestinal arterial embolization. Radiology 183:505–508 - PubMed
    1. Ferris FD, Bezjak A, Rosenthal SG (2001) The palliative uses of radiation therapy in surgical oncology patients. Surg Oncol Clin N Am 10:185–201 - PubMed
    1. Glimelius B, Hoffman K, Haglund U, Nyrén O, Sjödén PO (1994) Initial or delayed chemotherapy with best supportive care in advanced gastric cancer. Ann Oncol 5:189–190 - PubMed
    1. Hoskin PJ (1998) Radiotherapy in symptom management. In: Doyle D, Hanks GWC, Macdonald N (eds) Oxford textbook of palliative medicine, 2nd edn. Oxford University Press, New York, pp 278–280