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. 2009 Aug;135(8):1099-107.
doi: 10.1007/s00432-009-0551-2. Epub 2009 Feb 11.

Medical history and risk of lymphoma: results of a European case-control study (EPILYMPH)

Nikolaus Becker  1 , Joan Fortuny, Tomas Alvaro, Alexandra Nieters, Marc Maynadié, Lenka Foretova, Anthony Staines, Paul Brennan, Paolo Boffetta, Pier Luigi Cocco, Silvia de Sanjose
Affiliations

Medical history and risk of lymphoma: results of a European case-control study (EPILYMPH)

Nikolaus Becker et al. J Cancer Res Clin Oncol. 2009 Aug.

Abstract

Introduction: Lymphomas are a heterogeneous group of immune-cell malignancies. Immunology-related conditions are among the few factors for which consistent evidence exists relating them to lymphoma risk.

Materials and methods: We used the data from the European case-control study Epilymph on 2,362 lymphoma cases and 2,458 controls to investigate associations between a medical history of infectious and non-infectious diseases with overall and subentity-specific lymphoma risk.

Results: As key results, we observed an increased odds ratio (OR) for self-reported infections with hepatitis B virus (HBV, OR = 1.91, 95% CL = 1.24-2.94) and a null result for rheumatoid arthritis. Additionally, we found an increased OR for infectious mononucleosis (OR = 1.68, 95% CL = 1.14-2.48), an inverse association to frequency of sickness in childhood (OR = 0.68, 95% CL = 0.55-0.84), and-as casual finding-an increased OR with acetaminophen intake (OR = 2.29, 95% CL = 1.49-3.51).

Conclusion: Our results are consistent with the current knowledge about the association with mononucleosis as indicator of Epstein-Barr-virus infection, suggest serological study of the association to HBV infection and do not support the view of a positive association between rheumatoid arthritis and lymphoma risk.

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Figures

Fig. 1
Fig. 1
Medical history of rheumatoid arthritis (RA) and lymphoma risk with and without adjustment for RA-related medication (data for adjustment available from France, Germany and Spain)
See this image and copyright information in PMC

References

    1. Alexander DD, Mink PJ, Adamit H-O, Chang ET, Cole P, Mandel JS, Trichopoulos D (2007) The non-Hodgkin lymphomas: a review of the epidemiologic literature. Int J Cancer 120:1–39. doi:10.1002/ijc.22719 - DOI - PubMed
    1. Anderson LA, Pfeiffer R, Warren JL, Landgren O, Gadalla S, Berndt SI, Ricker W, Parsons R, Wheeler W, Engels EA (2008) Hematopoietic malignancies associated with viral and alcoholic hepatitis. Cancer Epidemiol Biomarkers Prev 17(11):3069–3075. doi:10.1158/1055-9965.EPI-08-0408 - DOI - PMC - PubMed
    1. Baecklund E, Ekbom A, Sparen P, Feltelius N, Klareskog L (1998) Disease activity and risk of lymphoma in patients with rheumatoid arthritis: nested case–control study. Br Med J 317:180–181 - PMC - PubMed
    1. Baris D, Zahm SH (2000) Epidemiology of lymphomas. Curr Opin Oncol 12:383–394. doi:10.1097/00001622-200009000-00002 - DOI - PubMed
    1. Becker N, Deeg E, Nieters A (2004) Population-based study of lymphomas in Germany: rationale, study design and first results. Leuk Res 28:713–724. doi:10.1016/j.leukres.2003.11.010 - DOI - PubMed

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