Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2009 Sep;15(9):1013-25.
doi: 10.1007/s00894-008-0365-1. Epub 2009 Feb 11.

Analysis of oligomeric proteins during unfolding by pH and temperature

Pradip Bhattacharya  1 , Tamil Ganeshan, Soumiyadeep Nandi, Alok Srivastava, Prashant Singh, Mohommad Rehan, Reshmi Rashkush, Naidu Subbarao, Andrew Lynn
Affiliations

Analysis of oligomeric proteins during unfolding by pH and temperature

Pradip Bhattacharya et al. J Mol Model. 2009 Sep.

Abstract

During thermal transition and variation of pH, structural properties of 35 proteins and their complexes (bound with substrate and co-factor) were analyzed in detail. During pH alteration, these proteins were shown to have substantial differences in conformations. pH conformers were analyzed in detail. Free energy and other energy parameters were also estimated for these proteins at various pH and temperatures. Detailed structural analysis and binding interfaces of various substrates, inhibitors and cofactor of these proteins were also investigated using docking and molecular dynamic simulation.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):10841-6 - PubMed
    1. Nature. 1992 Mar 5;356(6364):83-5 - PubMed
    1. Blood. 2003 Apr 1;101(7):2756-61 - PubMed
    1. Protein Sci. 1994 May;3(5):717-29 - PubMed
    1. Mol Biol Evol. 2006 Jun;23(6):1232-41 - PubMed

LinkOut - more resources