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. 2009;48(12):2148-51.
doi: 10.1002/anie.200804804.

Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA

Xiang Zheng  1 , Ulysses W Sallum, Sarika Verma, Humra Athar, Conor L Evans, Tayyaba Hasan
Affiliations

Exploiting a bacterial drug-resistance mechanism: a light-activated construct for the destruction of MRSA

Xiang Zheng et al. Angew Chem Int Ed Engl. 2009.

Abstract

A cunning and dangerous plan foiled! An enzyme-specific molecular construct exploits the overexpression of beta-lactamase in several drug-resistant bacteria. Specific photodynamic toxicity was detected towards beta-lactam-resistant methicillin-resistant Staphylococcus aureus (MRSA), whereby the usual mechanism for antibiotic resistance (cleavage of the beta-lactam ring) releases the phototoxic component from the prodrug (see picture; Q = quencher).

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