Comparative Study
doi: 10.1128/JVI.65.11.6334-6338.1991.
A novel cis-acting element that controls transcription of human immunodeficiency virus type 1 DNA, depending on cell type
Affiliations
- PMID: 1920636
- PMCID: PMC250349
- DOI: 10.1128/JVI.65.11.6334-6338.1991
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Comparative Study
A novel cis-acting element that controls transcription of human immunodeficiency virus type 1 DNA, depending on cell type
J Virol.
1991 Nov.
Abstract
cis-acting elements for the transcription of human immunodeficiency virus type 1 DNA were analyzed in cell-free transcription and DNA transfection assays. Besides previously identified cis elements, a region adjacent to the enhancer element was found to regulate transcription in both assays. Loss of this region caused 4.3- and 1.6-fold transcription inhibition in a transfection assay with a T-cell line, MOLT-4, and a monocyte line, U937, respectively, whereas the same region appeared to function negatively with other T-cell lines, MT-4 and Jurkat. These results suggest that this novel cis element regulates the transcription of proviral DNA in a cell-type-specific manner.
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