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. 2009 Feb 11:9:51.
doi: 10.1186/1471-2407-9-51.

Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status

Seon-Ah Ha  1 , Youn Soo Lee, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Hong Namkoong, Hae Joo Kim, Sang Min Jung, Yu Sun Lee, Yeun Jun Chung, Sang Seol Jung, Jin Woo Kim
Affiliations

Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status

Seon-Ah Ha et al. BMC Cancer. .

Abstract

Background: Oncoprotein HCCR-1 functions as a negative regulator of the p53 and contributes breast tumorigenesis. The serum HCCR-1 assay is useful in diagnosing breast cancer and mice transgenic for HCCR developed breast cancers. But it is unknown how HCCR-1 contributes to human breast tumorigenesis.

Methods: Oncogene HCCR-1 expression levels were determined in normal breast tissues, breast cancer tissues and cancer cell lines. We examined whether HCCR-1 protein expression in breast cancer is related to different biological characteristics, including ER, PR, p53 genotype, and HER2 status in 104 primary breast cancer tissues using immunohistochemical analyses.

Results: HCCR-1 was upregulated in breast cancer cells and tissues compared with normal breast tissues. In this study, overexpression of HCCR-1 was well correlated with known breast cancer prognostic markers including the presence of steroid receptors (ER and PR), p53 mutation and high HER2 overexpression. HCCR-1 was not detected in the ER-negative, PR-negative, p53 negative and low HER2 breast cancer tissues. These data indicate that the level of HCCR-1 in breast cancer tissues is relatively well correlated with known breast cancer factors, including the HER2 overexpression, p53 mutation, and ER/PR status.

Conclusion: Determination of HCCR-1 levels as options for HER2 testing is promising although it needs further evaluation.

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Figures

Figure 1
Figure 1
HCCR-1 expressions in breast cancers. Northern analyses of HCCR-1 in human breast tissues and cell lines. Comparison of HCCR-1 mRNA expressions in breast cancer cell lines (BT-474, MCF-7 and MDA-MB-231), and fresh primary breast cancer tissues (C) and their corresponding normal counterparts (N). Human β-actin cDNA was used as a control probe (bottom panel).
Figure 2
Figure 2
HCCR-1 is positively well correlated with breast cancer prognostic parameters. Correlation of HCCR-1 expression levels with known breast cancer prognostic parameters. Immunohistochemical staining for ER, PR, HER2, p53 and HCCR-1 in fresh frozen tissues from human breast cancers. All the breast cancer tissues were derived from pathologically-proven invasive ductal carcinomas. Positive immunostaining for ER, PR, and p53 in the nuclei of carcinoma cells and for HCCR-1 in the cytoplasm of carcinoma cells (top panel). The HER2 immunohistochemical staining showing complete strong membrane staining (3+) in the carcinoma cells (top panel). Negative immunostaining for ER, PR, p53, HER2 and HCCR-1 in breast carcinoma (bottom panel). Original magnification, × 100.
See this image and copyright information in PMC

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