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. 2009 Mar;36(3):508-11.
doi: 10.3899/jrheum.080724. Epub 2009 Feb 4.

The influence of sex on patients with rheumatoid arthritis in a large observational cohort

Noriko Iikuni  1 , Eri Sato, Masaya Hoshi, Eisuke Inoue, Atsuo Taniguchi, Masako Hara, Taisuke Tomatsu, Naoyuki Kamatani, Hisashi Yamanaka
Affiliations

The influence of sex on patients with rheumatoid arthritis in a large observational cohort

Noriko Iikuni et al. J Rheumatol. 2009 Mar.

Abstract

Objective: To compare the sex differences of various components of rheumatoid arthritis (RA).

Methods: Data of 4823 patients from a large observational cohort study were analyzed. Remarkable differences were noted between the sexes, and overall, women had significantly higher disease activity.

Results: When variables were adjusted using sex, age, and duration, Health Assessment Questionnaire, rather than Disease Activity Score, contributed most to sex difference. Further analysis showed evidence that progression of disability was approximately 3 times more rapid in female patients compared to male patients.

Conclusion: Women overall have higher RA disease activity and are prone to greater and faster progression of disability over time.

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