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Case Reports
. 2009 Mar;28(3):254-5.
doi: 10.1097/INF.0b013e31818c8ea5.

Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome

Isabel Cristina Ramos Melo Sampaio  1 , Maria João Rodrigo, José Gonçalo Duque Pereira Monteiro Marques
Affiliations
Case Reports

Two siblings with periodic fever, aphthous stomatitis, pharyngitis, adenitis (PFAPA) syndrome

Isabel Cristina Ramos Melo Sampaio et al. Pediatr Infect Dis J. 2009 Mar.

Abstract

PFAPA syndrome (periodic fever, aphthous stomatitis, pharyngitis, adenitis) is a benign sporadic syndrome of unknown cause. We report 2 siblings diagnosed with this syndrome. The second case started crisis simultaneously with recurrence of crisis after a 3-year free interval in her brother. This temporal relation suggests environmental factor acting in genetically predisposed children.

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