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. 2008 Aug;4(4):733-8.
doi: 10.2147/tcrm.s3091.

Fospropofol disodium injection for the sedation of patients undergoing colonoscopy

Benjamin E Levitzky  1 , John J Vargo
Affiliations

Fospropofol disodium injection for the sedation of patients undergoing colonoscopy

Benjamin E Levitzky et al. Ther Clin Risk Manag. 2008 Aug.

Abstract

Sedation plays a central role in making colonoscopy tolerable for patients and feasible for the endoscopist to perform. The array of agents used for endoscopic sedation continues to evolve. Fospropofol (FP), a prodrug of propofol with a slower pharmacokinetic profile, is currently under evaluation for use during endoscopic procedures. Preliminary data suggests that FP dosed at 6.5 mg/kg is well tolerated by most patients with perineal paresthesias being the most commonly experienced adverse effect. This article will examine the current literature on the use of FP for the sedation of patients undergoing colonoscopy, highlighting the pharmacokinetics, pharmacodynamics, risks, and common adverse events associated with the novel sedative/hypnotic.

Keywords: Aquavan; colonoscopy; fospropofol; propofol; sedation.

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Figures

Figure 1
Figure 1
Metabolism of fospropofol.
Figure 2
Figure 2
Mean (±1 SD) plasma propofol concentration after 10 mg/kg bolus dose of fospropofol vs 50 mg/min infusion of propofol x 3–4 minutes in 12 healthy subjects. Reprinted with permission from Shah A, Fechner J, Struys M, et al 2007. Differential PK/PD of propofol after intravenous fospropofol and diprivan in healthy subjects.Anesthesiology, 107:A46.
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