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Review
. 2008 Dec;12(6B):2525-32.
doi: 10.1111/j.1582-4934.2008.00509.x.

mTOR-dependent signalling in Alzheimer's disease

Jin-Jing Pei  1 , Jacques Hugon
Affiliations
Review

mTOR-dependent signalling in Alzheimer's disease

Jin-Jing Pei et al. J Cell Mol Med. 2008 Dec.

Abstract

Neurodegeneration and neurofibrillary degeneration are the two main pathological mechanisms of cognitive impairments in Alzheimer's disease (AD). It is not clear what factors determine the fates of neurons during the progress of the disease. Emerging evidence has suggested that mTOR-dependent signalling is involved in the two types of degeneration in AD brains. This review focuses on the roles of mTOR-dependent signalling in the pathogenesis of AD. It summarizes the recent advancements in the understanding of its roles in neurodegeneration and neurofibrillary degeneration, as well as the evidence achieved when mTOR-related signalling components were tested as potential biomarkers of cognitive impairments in the clinical diagnosis of AD.

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Figures

Fig. 1
Fig. 1
This figure summarizes the downstream signalling targets of mTORC1 and the consequences of their activation on translation.
Fig. 2
Fig. 2
This figure summarizes the possible effects of cellular stresses in neurons observed in Alzheimer's disease. In sensitive neurons to stress, it is proposed that mTOR and p70S6K activations as well as tau phosphorylation are reduced whereas in more resistant neurons, these signalling pathway are maintained.
See this image and copyright information in PMC

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Publication types