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Review
. 2009 Feb 10;19(3):R115-7.
doi: 10.1016/j.cub.2008.12.019.

Selfish DNA: homing endonucleases find a home

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Free article
Review

Selfish DNA: homing endonucleases find a home

David R Edgell. Curr Biol. .
Free article

Abstract

Self-splicing group I introns come in two flavours - those with a homing endonuclease to promote mobility of the intron, and those without an endonuclease. How homing endonucleases and self-splicing introns associate to form a composite selfish genetic element is a question of long-standing interest. Recent work has revealed that a shared characteristic of both introns and endonucleases, the targeting of conserved sequences, may provide the impetus for the evolution of composite mobile genetic elements.

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