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Multicenter Study
. 2009 Mar;4(3):609-15.
doi: 10.2215/CJN.04100808. Epub 2009 Feb 11.

Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA

Joachim H Ix  1 , Ian H De Boer, Carmen A Peralta, Kathryn L Adeney, Daniel A Duprez, Nancy S Jenny, David S Siscovick, Bryan R Kestenbaum
Affiliations
Multicenter Study

Serum phosphorus concentrations and arterial stiffness among individuals with normal kidney function to moderate kidney disease in MESA

Joachim H Ix et al. Clin J Am Soc Nephrol. 2009 Mar.

Abstract

Background and objectives: Higher phosphorus levels are associated with cardiovascular disease (CVD) events and mortality. Whether vascular stiffness may be responsible is unknown.

Design, setting, participants, & measurements: This study examined the cross-sectional associations of serum phosphorus with ankle brachial index (ABI), pulse pressure, and large and small artery elasticity by radial artery waveform analysis among 1370 individuals (440 with moderate chronic kidney disease) who did not have clinical CVD and participated in the Multi-Ethnic Study of Atherosclerosis.

Results: Fifty-nine (4%) individuals had high ABI (>1.30), a marker of peripheral arterial stiffness. Participants with phosphorus levels >4 mg/dl had greater than four-fold risk for high ABI compared with participants with phosphate levels <3 mg/dl (relative risk 4.6; 95% confidence interval 1.6 to 13.2; P = 0.01) after adjustment for demographics, traditional CVD risk factors, and kidney function. Higher phosphorus levels were also associated with greater pulse pressure and lesser large and small artery elasticity in unadjusted models, but these associations were attenuated after adjustment.

Conclusions: Higher phosphorus levels are strongly associated with high ABI but not pulse pressure or large or small artery elasticity. If confirmed in future studies, then the association of higher phosphorus concentrations with CVD events may be partially mediated through peripheral arterial stiffness.

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Figures

Figure 1.
Figure 1.
Prevalence of high ankle brachial index (ABI) by serum phosphorus concentrations in the Multi-Ethnic Study of Atherosclerosis (MESA).
Figure 2.
Figure 2.
Prevalence of Low ankle brachial index (ABI) by serum phosphorus concentration in the Multi-Ethnic Study of Atherosclerosis.
See this image and copyright information in PMC

References

    1. Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB Sr, Gaziano JM, Vasan RS: Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 167: 879–885, 2007 - PubMed
    1. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G: Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 112: 2627–2633, 2005 - PubMed
    1. Moe SM, Chen NX: Mechanisms of vascular calcification in chronic kidney disease. J Am Soc Nephrol 19: 213–216, 2008 - PubMed
    1. Giachelli CM, Jono S, Shioi A, Nishizawa Y, Mori K, Morii H: Vascular calcification and inorganic phosphate. Am J Kidney Dis 38: S34–S37, 2001 - PubMed
    1. Giachelli CM, Speer MY, Li X, Rajachar RM, Yang H: Regulation of vascular calcification: Roles of phosphate and osteopontin. Circ Res 96: 717–722, 2005 - PubMed

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