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Review
. 2009 May;83(9):4000-12.
doi: 10.1128/JVI.02417-08. Epub 2009 Feb 11.

Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation

Andrew N Blackford  1 , Roger J A Grand
Affiliations
Review

Adenovirus E1B 55-kilodalton protein: multiple roles in viral infection and cell transformation

Andrew N Blackford et al. J Virol. 2009 May.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Sequence alignment of E1B-55K proteins. A representative member of each subgroup is shown: Ad12 from group A, Ad11 from group B, Ad5 from group C, Ad9 from group D, Ad4 from group E, and Ad40 from group F. Letters with a black background are residues conserved among all subgroups; letters with a gray background are residues conserved among some subgroups. Alignments were produced and edited using the ClustalW and GeneDoc programs.
FIG. 2.
FIG. 2.
Linear representation of the Ad5 E1B-55K protein. Arrows indicate residues known to be sumoylated (K104) or phosphorylated (S490/S491/T495). Gray boxes indicate different motifs in the E1B-55K polypeptide. RNP, RNP motif; C2H2, putative zinc finger.
FIG. 3.
FIG. 3.
Ad5 E1B-55K and E4orf6 proteins form an E3 ubiquitin ligase complex that targets substrates such as p53 for proteasomal degradation. E2, ubiquitin-conjugating enzyme; Ub, ubiquitin.
See this image and copyright information in PMC

References

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