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Case Reports
. 2009 Sep;80(9):872-4.
doi: 10.1007/s00104-009-1671-6.

[Heparin-induced thrombocytopenia and liver hemorrhage following polytrauma]

[Article in German]
E Liodakis  1 , F Hildebrand, M Frink, P Mommsen, C Krettek, C Probst
Affiliations
Case Reports

[Heparin-induced thrombocytopenia and liver hemorrhage following polytrauma]

[Article in German]
E Liodakis et al. Chirurg. 2009 Sep.

Abstract

Up to 3% of patients receiving unfractioned heparin develop heparin-induced thrombocytopenia (HIT). We report on a polytrauma patient who developed severe HIT with bilateral pulmonary embolism. Lepirudin treatment resulted initially in rapid improvement. Ten days after discharge the patient complained of abdominal pain. A large subcapsular hepatic hematoma was diagnosed, requiring repeat surgery and ending in secondary sclerosing cholangitis. This process can potentially be avoided by regular tests of lepirudin concentration and coagulation.

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References

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