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Case Reports
. 2009 Feb 12;360(7):692-8.
doi: 10.1056/NEJMoa0802905.

Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

Gero Hütter  1 , Daniel Nowak, Maximilian Mossner, Susanne Ganepola, Arne Müssig, Kristina Allers, Thomas Schneider, Jörg Hofmann, Claudia Kücherer, Olga Blau, Igor W Blau, Wolf K Hofmann, Eckhard Thiel
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Free article
Case Reports

Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation

Gero Hütter et al. N Engl J Med. .
Free article

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) requires the presence of a CD4 receptor and a chemokine receptor, principally chemokine receptor 5 (CCR5). Homozygosity for a 32-bp deletion in the CCR5 allele provides resistance against HIV-1 acquisition. We transplanted stem cells from a donor who was homozygous for CCR5 delta32 in a patient with acute myeloid leukemia and HIV-1 infection. The patient remained without viral rebound 20 months after transplantation and discontinuation of antiretroviral therapy. This outcome demonstrates the critical role CCR5 plays in maintaining HIV-1 infection.

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Comment in

  • Not an HIV cure, but encouraging new directions.
    Levy JA. Levy JA. N Engl J Med. 2009 Feb 12;360(7):724-5. doi: 10.1056/NEJMe0810248. N Engl J Med. 2009. PMID: 19213687 No abstract available.
  • HIV "cure": A shot in the arm?
    Peluso MJ, Deeks SG, McCune JM. Peluso MJ, et al. EBioMedicine. 2019 Apr;42:3-5. doi: 10.1016/j.ebiom.2019.04.011. Epub 2019 Apr 11. EBioMedicine. 2019. PMID: 30982768 Free PMC article. No abstract available.

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