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. 1977 Mar;22(3):247-52.

[Superinduction of interferon and and a study of its messenger RNA]

[Article in Russian]
F I Ershov, T M Sokolova, A A Kadyrova
  • PMID: 192141

[Superinduction of interferon and and a study of its messenger RNA]

[Article in Russian]
F I Ershov et al. Antibiotiki. 1977 Mar.

Abstract

Combined use of interferon inductor poly-IC and antibiotics (cycloheximide and actinomycin D) provided a significant increase (up to 1000 times) in interferon production by chick, mouse, monkey and human cells. Messenger RNA with matrix activity for interferon (mRNA-IF) was isolated from superinduced cells. On translation of mRNA-IF in homogenous and heterogenous cells the specificity of interferons produced was determined by the type of the cells from which mRNA-IF was isolated. Sedimentation analysis of various mRNA-IF revealed 2 peaks of activity: major (5--15S) and minor (25--30S).

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