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. 1977 Jul-Aug;5(4):363-7.

The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites

A J Ryan, J R Bend
  • PMID: 19215

The metabolism of styrene oxide in the isolated perfused rat liver. Identification and quantitation of major metabolites

A J Ryan et al. Drug Metab Dispos. 1977 Jul-Aug.

Abstract

Isolated perfused rat livers rapidly metabolized 14C-styrene oxide. A large proportion of the administered radioactivity was excreted in the bile as a single compound that was identified as S-(1-phenyl-2-hydroxyethyl)glutathione by comparison with an authentic synthetic standard. The circulating perfusate was found to contain approximately equal amounts of styrene glycol, mandelic acid, and the glutathione derivative.

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