Review
doi: 10.1016/j.devcel.2009.01.021.
A new G(q)-initiated MAPK signaling pathway in the heart
- PMID: 19217418
- DOI: 10.1016/j.devcel.2009.01.021
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Review
A new G(q)-initiated MAPK signaling pathway in the heart
Dev Cell.
2009 Feb.
Free article
Abstract
Pathological cardiac hypertrophy involves auto/paracrine mediators acting through G(q/11)-coupled receptors. A novel signaling route stimulated by betagamma-subunits of G(q/11) results in the autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby activating hypertrophic gene programs.
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