Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Feb;16(2):163-4.
doi: 10.1016/j.devcel.2009.01.021.

A new G(q)-initiated MAPK signaling pathway in the heart

J Silvio Gutkind, Stefan Offermanns
Free article
Review

A new G(q)-initiated MAPK signaling pathway in the heart

J Silvio Gutkind et al. Dev Cell. 2009 Feb.
Free article

Abstract

Pathological cardiac hypertrophy involves auto/paracrine mediators acting through G(q/11)-coupled receptors. A novel signaling route stimulated by betagamma-subunits of G(q/11) results in the autophosphorylation of ERK1/2 on a new site and the nuclear retention of ERK1/2, thereby activating hypertrophic gene programs.

PubMed Disclaimer

Substances

LinkOut - more resources