Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2009 Jul 1;39(8):895-901.
doi: 10.1016/j.ijpara.2009.02.004. Epub 2009 Feb 13.

Toxoplasmosis: A history of clinical observations

Louis M Weiss  1 , Jitender P Dubey
Affiliations
Review

Toxoplasmosis: A history of clinical observations

Louis M Weiss et al. Int J Parasitol. .

Abstract

It has been 100 years since Toxoplasma gondii was initially described in Tunis by Nicolle and Manceaux (1908) in the tissues of the gundi (Ctenodoactylus gundi) and in Brazil by Splendore (1908) in the tissues of a rabbit. Toxoplasma gondii is a ubiquitous, Apicomplexan parasite of warm-blooded animals that can cause several clinical syndromes including encephalitis, chorioretinitis, congenital infection and neonatal mortality. Fifteen years after the description of T. gondii by Nicolle and Manceaux a fatal case of toxoplasmosis in a child was reported by Janků. In 1939 Wolf, Cowen and Paige were the first to conclusively identify T. gondii as a cause of human disease. This review examines the clinical manifestations of infection with T. gondii and the history of the discovery of these manifestations.

PubMed Disclaimer

References

    1. Ajioka JW, Soldati D. preface. In: Ajioka JW, Soldati D, editors. Toxoplasma Molecular and Cellular Biology. Horizon Bioscience; Norfolk: 2007. pp. xii–xviii.
    1. Bahia-Oliveira LM, Jones JL, Azevedo-Silva J, Alves CC, Orefice F, Addiss DG. Highly endemic, waterborne toxoplasmosis in north Rio de Janeiro state, Brazil. Emerg Infect Dis. 2003;9:55–62. - PMC - PubMed
    1. Belfort-Neto R, Nussenblatt V, Rizzo L, Muccioli C, Silveira C, Nussenblatt R, Khan A, Sibley LD, Belfort R., Jr High prevalence of unusual genotypes of Toxoplasma gondii infection in pork meat samples from Erechim, Southern Brazil. An Acad Bras Cienc. 2007;79:111–114. - PubMed
    1. Beverley JKA, Beattie CP. Glandular toxoplasmosis. A survey of 30 cases Lancet. 1958;23:379–384. - PubMed
    1. Bowie WR, King AS, Werker DH, Isaac-Renton JL, Bell A, Eng SB, Marion SA. Outbreak of toxoplasmosis associated with municipal drinking water. The BC Toxoplasma Investigation Team. Lancet. 1997;350:173–177. - PubMed

MeSH terms