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Comment
. 2009 Mar;5(3):129-30; author reply 130.
doi: 10.1038/nchembio0309-129.

Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex

Kristen M Garner, Alexandre A Pletnev, Alan Eastman
Comment

Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex

Kristen M Garner et al. Nat Chem Biol. 2009 Mar.
No abstract available

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Figures

Figure 1
Figure 1
(a) The structures of compounds discussed in the text; compound 3 is the corrected structure for mirin. (b) Mirin causes a G2 arrest. MDA-MB-231 cells were incubated with or without 100 μM Mirin for 24 h, then fixed, stained with propidium iodide and analyzed by flow cytometry. (c) Mirin inhibits the phosphorylation of ATM. MDA-MB-231 cells were incubated with mirin for 1 h, irradiated (10 Gy) and cell lysates made 30 min later. Western blots were probed for ATM (Abcam) and p(S1981)ATM (Epitomics). Panels b and c should be compared to similar experiments of Dupre et al..
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