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. 1977 Jan 1;161(1):21-5.
doi: 10.1042/bj1610021.

A functioning complex between tryptic fragments of cytochrome c. A route to the production of semisynthetic analogues

D E Harris, R E Offord

A functioning complex between tryptic fragments of cytochrome c. A route to the production of semisynthetic analogues

D E Harris et al. Biochem J. .

Abstract

We report the discovery of a functioning non-covalent complex between two peptides obtained from a limited tryptic digest of horse heart cytochrome c. We have used the phenomenon to produce three modified versions of the complex. We have replaced lysine-39 semisynthetically with ornithine in the first analogue, with p-fluorophenyl-alanine in the second, and removed it entirely in the third.

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