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Comment
. 2009 Feb 12;113(7):1395-6.
doi: 10.1182/blood-2008-11-185801.

MLL5 governs hematopoiesis: a step closer

Han Liu  1 , Todd D Westergard, James J-D Hsieh
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MLL5 governs hematopoiesis: a step closer

Han Liu et al. Blood. .
Free article

Abstract

MLL5 is an MLL family protein and a candidate tumor suppressor located within the human chromosome band 7q22 that is frequently deleted in myeloid malignancies. In this issue of Blood, 3 independent studies report the first genetic analysis of MLL5 deficiency in mice. All 3 strains of MLL5 knockout mice exhibited defects in hematopoiesis, highlighting the critical role of MLL5 in hematopoietic stem cell functions.

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