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. 2009 Jun;178(2):173-8.
doi: 10.1007/s11845-009-0291-y. Epub 2009 Feb 17.

The effects of diet and orlistat on body weight and lipid profiles in high risk Chinese patients with coronary artery disease, obesity and hypercholesterolemia

K W Chan  1 , W S Leung, Y S Fung, H F Hung, P Tsui, H Chu, Y W Chan, G T C Ko, V T F Yeung
Affiliations

The effects of diet and orlistat on body weight and lipid profiles in high risk Chinese patients with coronary artery disease, obesity and hypercholesterolemia

K W Chan et al. Ir J Med Sci. 2009 Jun.

Abstract

Background: Orlistat is a gastrointestinal lipase inhibitor approved for use in obesity. So far, no evidence has been reported on the use of orlistat in obese patients with coronary artery disease (CAD).

Aim: To investigate the effect of orlistat on body weight and lipid profiles in obese patients with CAD and hypercholesterolemia.

Methods: Thirty non-diabetic patients with CAD, body mass index (BMI) > or = 25 kg/m(2) and low-density lipoprotein cholesterol (LDL-C) > or = 2.6 and < 4.1 mmol/L were put on diet for 12 weeks. Those still having a BMI > or = 25 kg/m(2) received orlistat 120 mg thrice daily for another 24 weeks.

Results: BMI was significantly reduced by 1.7% after 12 weeks of dietary treatment. The 24-week orlistat treatment resulted in further significant reduction in BMI (-2.8%) and LDL-C (-7.0%).

Conclusion: Diet and orlistat treatment significantly reduced BMI and improved LDL-C in obese patients with CAD and hypercholesterolemia.

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