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. 2009 Jun 8;278(1):113-21.
doi: 10.1016/j.canlet.2009.01.004. Epub 2009 Feb 14.

Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

Yanke Chen  1 , Hongxin Zhang, Xingchun Gou, Yohei Horikawa, Jinliang Xing, Zhinan Chen
Affiliations

Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

Yanke Chen et al. Cancer Lett. .

Abstract

Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.

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