doi: 10.3390/molecules14020763.
Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones
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- PMID: 19223824
- PMCID: PMC6254017
- DOI: 10.3390/molecules14020763
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Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones
Molecules.
.
Abstract
A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.
Figures
Cu(NH2SO3)2-catalyzed Biginelli reaction.
Mechanism of the Biginelli reaction catalyzed by Cu(NH2SO3)2.
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