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. 2009 Feb 13;14(2):763-70.
doi: 10.3390/molecules14020763.

Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones

Chen-Jiang Liu  1 , Ji-De Wang
Affiliations

Copper(II) sulfamate: an efficient catalyst for the one-pot synthesis of 3,4-dihydropyrimidine-2(1H)-ones and thiones

Chen-Jiang Liu et al. Molecules. .

Abstract

A simple, efficient procedure for the one-pot Biginelli condensation reaction of aldehydes, beta-ketoesters and urea or thiourea employing copper(II) sulfamate as a novel catalyst is described. Compared to the classical Biginelli reaction conditions, the present method has the advantages of good yields, short reaction times and experimental simplicity.

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Figures

Scheme 1
Scheme 1
Cu(NH2SO3)2-catalyzed Biginelli reaction.
Scheme 2
Scheme 2
Mechanism of the Biginelli reaction catalyzed by Cu(NH2SO3)2.
See this image and copyright information in PMC

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