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. 2009 Mar 10;100(5):680-3.
doi: 10.1038/sj.bjc.6604940. Epub 2009 Feb 17.

Poor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumours

S M Tovey  1 , S Brown, J C Doughty, E A Mallon, T G Cooke, J Edwards
Affiliations

Poor survival outcomes in HER2-positive breast cancer patients with low-grade, node-negative tumours

S M Tovey et al. Br J Cancer. .

Abstract

We present a retrospective analysis on a cohort of low-grade, node-negative patients showing that human epidermal growth factor receptor 2 (HER2) status significantly affects the survival in this otherwise very good prognostic group. Our results provide support for the use of adjuvant trastuzumab in patients who are typically classified as having very good prognosis, not routinely offered standard chemotherapy, and who as such do not fit current UK prescribing guidelines for trastuzumab.

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Figures

Figure 1
Figure 1
Kaplan–Meier curves for HER2 status. Survival curves showing cumulative survival differences (end point=breast cancer-specific survival) between patients positive or negative for HER2. P-value represents log-rank testing of the difference in cumulative survival.
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