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Comparative Study
. 2009 Nov;467(11):2939-48.
doi: 10.1007/s11999-009-0749-2. Epub 2009 Feb 18.

Prognostic factors for survival in patients with epithelioid sarcoma: 441 cases from the SEER database

Muhammad Umar Jawad  1 , Jason Extein, Elijah S Min, Sean P Scully
Affiliations
Comparative Study

Prognostic factors for survival in patients with epithelioid sarcoma: 441 cases from the SEER database

Muhammad Umar Jawad et al. Clin Orthop Relat Res. 2009 Nov.

Abstract

Current stratification of prognosis in patients with epithelioid sarcoma (ES) is based largely on data reported by individual centers with a limited number of patients. We sought to identify the important prognostic parameters using the Surveillance, Epidemiology, and End Results (SEER) database. We identified 441 patients with ES in the database and extracted information regarding patient demographics and clinical characteristics. Kaplan-Meier, log-rank, and Cox regression were used for analysis. Disease-specific survival declined until 100 months after diagnosis after which survival was unrelated to epithelioid sarcoma. The overall incidence of ES during 2005 was 0.041 per 100,000. The reported incidence has increased since 1973, with an annual percentage change of 5.217%. On multivariate analysis, only age younger than 16 years, local stage of disease, or negative nodes and surgical resection of the tumor predicted better disease-specific survival. We observed no increase in survival by comparing decades of diagnosis since 1986. The SEER database shows only age younger than 16 years, negative nodes, or local stage of disease and operability of primary disease independently predict survival in patients with ES.

Level of evidence: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.

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Figures

Fig. 1A–B
Fig. 1A–B
(A) A graph shows the overall incidence of ES plotted by year of diagnosis and normalized to the US 2000 census. (B) An age-adjusted histogram depicts the incidence rate of ES normalized to the US 2000 census.
Fig. 2A–E
Fig. 2A–E
Kaplan-Meier plots depict (A) overall survival (mean = 155 months, 95% CI = 134.98–175.01 months), (B) disease-specific survival (mean = 239.23 months, 95% CI = 217.45–261.01 months), and disease-specific survival estimates for patients with ES stratified by (C) age, (D) stage, and (E) surgery (corresponding data in Table 2).
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