Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 2009 Apr;22(2):238-41.
doi: 10.1111/j.1755-148X.2009.00550.x. Epub 2009 Feb 17.

Long-lasting pigmentation of human skin, a new look at an overlooked response to UV

Sergio G Coelho, Yanchun Zhou, Harry F Bushar, Sharon A Miller, Barbara Z Zmudzka, Vincent J Hearing, Janusz Z Beer
Clinical Trial

Long-lasting pigmentation of human skin, a new look at an overlooked response to UV

Sergio G Coelho et al. Pigment Cell Melanoma Res. 2009 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
LLP ≥9 months after ultraviolet (UV) exposure in six phototypes (1 - Burns easily, never tans; 2 - Burns easily, tans slightly; 3 - Burns slightly, tans light brown; 4 -Burns slightly, tans moderate brown; 5 - Burns rarely, tans dark brown; 6 Never burns, tans black). The black squares show the areas with LLP, enlarged on the right side with doses in multiples of MED included. The subject numbers are given in parentheses.
Figure 2
Figure 2
Pigmentation after 1–4 MED of UV.
Figure 3
Figure 3
Increasing MED, MMD, and frequency of LLP induction. (A) MED ranges, (B) MMD ranges - as defined in Appendix S1. Total number of subjects, 64; data for 62, 64, 60, 43, and 28 subjects at 1, 1.4, 2, 2.8, and 4 MED, respectively.
See this image and copyright information in PMC

References

    1. Aoki H, Moro O, Tagami H, Kishimoto J. Gene expression profiling analysis of solar lentigo in relation to immunohistochemical characteristics. Br J Dermatol. 2007;156:1214–1223. - PubMed
    1. Brenner M, Coelho SG, Beer JZ, Miller SA, Wolber R, Smuda C, Hearing VJ. Long-Lasting Molecular Changes in Human Skin after Repetitive In Situ UV Irradiation. J Invest Dermatol. 2009;129:1002–11. - PMC - PubMed
    1. Gilchrest BA, Blog FB, Szabo G. Effects of aging and chronic sun exposure on melanocytes in human skin. J Invest Dermatol. 1979;73:141–143. - PubMed
    1. Honigsmann H, Schuler G, Aberer W, Romani N, Wolff K. Immediate pigment darkening phenomenon. A reevaluation of its mechanisms. J Invest Dermatol. 1986;87:648–652. - PubMed
    1. Moyal D, Chardon A, Kollias N. Determination of UVA protection factors using the persistent pigment darkening (PPD) as the end point. (Part 1) Calibration of the method. Photodermatol Photoimmunol Photomed. 2000;16:245–249. - PubMed