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Editorial
. 2009 Feb 19;360(8):813-5.
doi: 10.1056/NEJMe0810213.

Metabolic enzymes as oncogenes or tumor suppressors

Craig B Thompson
Editorial

Metabolic enzymes as oncogenes or tumor suppressors

Craig B Thompson. N Engl J Med. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

Figures

Figure 1
Figure 1. The Roles of IDH1, IDH2, Succinate Dehydrogenase, and Fumarase in Cellular Metabolism
CytoOx denotes mitochondrial cytochrome oxidase, HIF-1 hypoxia-inducible factor 1, HIF-1-OH hydroxylated HIF-1, IDH isocitrate dehydrogenase, SDH succinate dehydrogenase, VEGF vascular endothelial growth factor, and VHL von Hippel–Lindau tumor-suppressor protein.
See this image and copyright information in PMC

Comment on

  • IDH1 and IDH2 mutations in gliomas.
    Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, Kos I, Batinic-Haberle I, Jones S, Riggins GJ, Friedman H, Friedman A, Reardon D, Herndon J, Kinzler KW, Velculescu VE, Vogelstein B, Bigner DD. Yan H, et al. N Engl J Med. 2009 Feb 19;360(8):765-73. doi: 10.1056/NEJMoa0808710. N Engl J Med. 2009. PMID: 19228619 Free PMC article.

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