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Review
. 2009 Feb;64(2):175-8.
doi: 10.1093/gerona/gln065. Epub 2009 Feb 19.

Does damage to DNA and other macromolecules play a role in aging? If so, how?

Judith Campisi  1 , Jan Vijg
Affiliations
Review

Does damage to DNA and other macromolecules play a role in aging? If so, how?

Judith Campisi et al. J Gerontol A Biol Sci Med Sci. 2009 Feb.

Abstract

One of the most pervasive ideas regarding the causes of aging is that longevity is constrained in large measure by damage to macromolecules. An increasing body of cellular and molecular data, generated over the past decade or so, has generally supported this "damage accumulation" hypothesis of aging. There remain unanswered questions regarding which types of damage are most important for driving aging. In addition, there have been recent challenges to the damage accumulation hypothesis and a new emphasis on the importance of cellular responses and the sequelae to damage, rather damage per se. New tools and approaches are on the horizon and will need to be developed and implemented before we can fully understand whether and to what extent macromolecular damage drives aging phenotypes.

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